Geumsan Ginseng Herb Development Agency

Maintenance and regulation of immune system homeostasis through immune cell activation

Korean ginseng restores the weakened or suppressed immune system and strengthens the immune system's resistance by stimulating, enhancing, and activating the overall immune system. (The latest Korean ginseng research, 2007)
The saponin and polysaccharide components of Korean ginseng activate natural killer cells (NK cells) that have the ability to destroy virus-infected cells or tumor cells, and cells that produce antibodies when pathogens such as viruses invade our body. It regulates the immune system through interactions such as activating macrophages that release cytokines, chemicals that respond to various types of immunity (Food Science and Industry 2012).

Improving resistance to viral infections such as flu, COVID-19, SARS, and AIDS

Korean ginseng exhibits preventive efficacy against viral infectious diseases such as influenza (flu), SARS, and COVID-19 by inhibiting inflammation, activating immune cells, and activating cell survival pathways.
As a result of ingesting Korean ginseng extract at 972 mg per day for 12 weeks for healthy adult men and women, the risk of respiratory infection was 25% lower in the group taking the Korean ginseng compared to the group taking the placebo. , the risk of infection was reduced by 41%, and the duration of infectious diseases such as sore throat, stuffy nose, cough, and headache was shortened by about 69% (J Ginseng Res 2020).

Anticancer effect through cancer prevention and inhibition of cancer cell proliferation and metastasis

Compared to those who do not take Korean ginseng, the incidence of various types of cancer including gastric cancer, liver cancer, and lung cancer is reduced compared to those who do not take Korean ginseng. (Int'l. J. Epidemiol. 1990, Mutat. Res 2003, Processes 2021)

If an organism does not promptly process waste products or free radicals generated during metabolic activities, cell organs and tissues are damaged and their function is reduced, causing physical performance or perception ability to be easily exhausted, that is, fatigue. (Med Sci Sports Exerc 2016)
In a human application test for 90 chronic fatigue patients, the group fed ginseng extract significantly decreased the level of reactive oxygen species, a fatigue-inducing substance, compared to the control group, and the fatigue perception symptoms and fatigue index were significantly improved ( PLOS ONE 2013)
Deep sleep recovers the body from various stressors or physically exhausted, and Korean ginseng is effective for people with sleep disorders by extending deep sleep time and reducing light sleep time to improve the quality of sleep. (Sleep Med Psychophysiol 2010) .

Ginseng is known to improve cardiovascular-related symptoms by improving blood circulation. In particular, it is known to protect against cardiomyocyte damage, inhibit platelet aggregation in blood vessels, and inhibit the occurrence of myocardial hypertrophy and heart failure.
Korean ginseng exhibits vasodilatory effects, inhibits platelet aggregation that contributes to arterial thrombus formation, and reduces lipopolysaccharide-mediated microcirculation disorders (Acta pharmacol Sin 2000, J Pharm Pharmacol 2008, J Microbiol biotechnol 2007).
Korean ginseng and its ingredients regulate blood lipid profile to weaken arteriosclerosis and protect blood vessel cells through antioxidant effects that inhibit lipid peroxidation caused by harmful reactive oxygen species (ROS). (J Ethnopharmacol 2009, Int J Biomed 2011) )

Korean ginseng has the effect of promoting learning, reviving long-term forgetfulness, or improving the memory lost by alcohol or drugs (Korean J Ginseng Sci 1996).
Korean ginseng extract, saponin and non-saponin (gintonin) components improve memory impairment by reducing the expression of amyloid-β peptide (Aβ), a major causative agent of Alzheimer's disease (AD). (J Ginseng Res 2018)
Administration of Korean ginseng reduces increased inflammatory mediators in aged brain tissue and improves memory by restoring decreased antioxidant-related enzymes. (J Mol Neurosci 2019)
Korean ginseng has a preventive effect on nerve cell damage and learning behavior disorder accompanying cerebral ischemia. (Neurochem Int 2020)

Korean ginseng improves related diseases by removing free radicals generated in vivo and increasing the expression and activity of antioxidant enzymes (SOD, Catalase, GPx, etc.). (Clin Interv Aging 2018)
In those who took 6 g of Korean ginseng powder for 8 weeks, the antioxidant enzyme SOD activity and GPx activity were significantly increased, and the lipid peroxide decreased significantly, confirming the antioxidant activity (Korean J Lipidol 2011).
Decrease in estrogen levels in postmenopausal women is closely related to the risk of cardiovascular disease. The antioxidant enzyme levels of postmenopausal women who consumed Korean ginseng showed higher antioxidant enzyme levels than the control group that did not consume Korean ginseng (J Ginseng Res). 2017)

Helps menopausal women's health

Estrogen is a female hormone produced by the primary ovary and is related to chronic diseases such as cardiovascular disease, brain disease, and porosity in addition to reproductive function. When the ovarian function decreases, the symptoms of menopause begin to appear along with a decrease in female hormones. Menopausal symptoms include hot flashes, sweating, insomnia, memory loss, decreased concentration, depression, vaginal dryness and urinary tract infection, and osteoporosis. (Hum Reprod Update 2017)
Korean ginseng through clinical trials related to menopausal symptoms showed excellent effects on sexual arousal and overall health, and positive effects on happiness and depression (Int J Clin Pharmacol Res 1999). , can improve blood lipids and cholesterol and prevent Alzheimer's. (J. Altern. Complement. Med 2020, Nutrients 2020)

Improving male sexual function

Male menopause is a clinical and biochemical syndrome accompanied by serum testosterone deficiency and typical symptoms such as erectile dysfunction, decreased libido, passive attitude, and osteoporosis that men experience with increasing age (J Korean Med Assoc 2011).
When Korean ginseng extract was administered to elderly rats at 200 mg/kg for 12 weeks, sperm motility and sperm production ability due to aging significantly improved compared to the control group, confirming improvement in testicular function. (Korea Ginseng Research and Industry, 2008)
When an adult with erectile dysfunction consumes Korean ginseng, the level of erectile dysfunction (IIEF) including erectile function area, climax, sexual desire, sexual satisfaction, and sexual life satisfaction are all significantly improved compared to the control group (Korean Journal of Urology 2009).

Bone density was increased by 32% in rats administered with ginseng extract to aging rats compared to the control group, and the content of osteocalcin and calcium, which are indicators of bone formation, also increased significantly. )
As a result of taking ginseng extract to women with osteopenia, osteocalcin (osteocalcin) content increased by 11.8 times and calcium content by 3.6 times compared to the control group taking placebo. showed (Report 2016 of the National Forest Academy of Horticultural and Herbal Science)

As a result of ingesting Korean ginseng extract for adults with slightly higher liver levels, the liver level, ALT level, and GGT level decreased by 15.67%, GGT level by 5.93%, AST level by 14.32%, and fatty liver index by 2.57% (Evidence-based Complementary). Alternative Medicine 2020)
When liver damage was induced by drugs after feeding rats with ginseng extract, the liver level in the control group increased about 5 times compared to the normal group, but when the ginseng extract was administered, it improved close to the normal level. In liver tissue analysis, the rats treated with the ginseng extract improved the hepatitis, necrosis and fibrosis indices such as inflammation, swelling, fat degeneration, and collagen deposition of hepatocytes caused by liver damage. Korean ginseng exhibits the effect of improving hepatitis by eliminating free radicals generated during liver damage and activating antioxidant enzymes such as SOD in liver tissue. (Nutrition Research and Practice 2020)

When Korean ginseng extract was given to people with impaired fasting blood glucose, impaired glucose tolerance, or type 2 diabetes, serum glucose levels decreased in a glucose tolerance test, and the plasma insulin sensitivity index increased by 33% compared to the placebo group (Molecule). 2019)
Korean ginseng can improve pancreatic β-cell function, enhance insulin sensitivity, regulate blood sugar levels, and improve glucose uptake by inducing glucose transporter (GLUT) expression (J Ethnopharmacol 2020)
Korean ginseng is effective in improving diabetic retinopathy, nephropathy, nerve pain, and cardiovascular complications by inhibiting oxidative stress and diabetic inflammation caused by diabetes. (J Med Food 2019, J Ginseng Res 2019)

Oxidative stress caused by ultraviolet light (UVB) induces the production of reactive oxygen species, leading to lipid peroxidation and various types of DNA damage. When Korean ginseng was administered to hairless mice irradiated with UV light, wrinkles, epidermal thickness, and skin dryness were improved, and collagen biosynthesis was increased (J Ginseng Res 2017).
Melanin, a major determinant of skin color, is produced excessively by ultraviolet rays to promote skin pigmentation and cancer formation.
In order to find out whether Korean ginseng extract is effective in suppressing skin aging caused by ultraviolet rays, a cream containing Korean ginseng extract was applied to evaluate the preventive effect on eye wrinkles. As a result, the photodamage score was significantly reduced, and the average roughness It was significantly reduced and showed excellent skin moisturizing and softening effects (Rejuvenation Res. 2015).

Efficacy of modern medicine Geumsan ginseng.